ABSTRACT
Objective@#To investigate the situation of social sports activities and the relationship with depression among junior middle school students, to provide evidence for depression intervention.@*Methods@#A total of 3 623 students from eight middle schools in Chengdu were recruited and surveyed by self-made questionnaire during Sept. to Dec. 2019 Z test, Chi-Square test and Logistic regression analysis were applied to explore influence factors.@*Results@#The prevalence of depression symptoms was 45.60%. 57.34% of the students liked social sports activities, 65.87% of them participated in social sports activities during the past week, 42.25% took less than 30 minutes on exercise while 22.24% took over 45 minutes. Among the students, 20.16% of them had no special feeling after social sports activities, while 31.88% felt sweat. Uni-variate analysis indicated that compared with boys, girls participated more frequently and got stronger feeling than boys (χ2/Z=6.28，-2.67，P<0.05). Regression results indicated that for boys, high grade,low education degree of mother, low household socioeconomic status, not the only-child ,exercise alone would significantly increase the risk of depression, while liking social sports activities was protective factor (OR=1.26，1.91，1.52，2.56，1.58，1.71，0.77，P<0.05). For girls, high grade,low education degree of father, without one-child would significantly increase the risk of depression, while like social sports activities was protective factor(OR=1.29，1.74，1.37，1.47，0.66，P<0.05).@*Conclusion@#Social sports activities could reduce depression symptoms, which can be considered as first choice as after-class activity among junior middle school students.
ABSTRACT
Abstract Purpose: To investigate the protective effects of Polygonatum sibiricum polysaccharide (PSP) on acute heart failure (AHF) in rats. Methods: Sixty rats were randomly divided into control, model, and low-, middle- and high-dose PSP groups, 12 rats in each group. The low-, medium- and high-dose PSP groups were intragastrically administrated with 100, 200 and 400 mg/kg PSP for 5 days, respectively. On the sixth day, the AHF model was established by intraperitoneal injection of adriamycin. After 24h, the cardiac function, serum biochemical indexes, myocardial ATPase and succinate dehydrogenase levels and apoptosis related protein expressions were determined. Results: Compared with model group, in high-dose PSP group the heart rate, left ventricular systolic pressure, ±dp/dtmax, serum superoxide dismutase level, myocardial Na+-K+-ATPase, Ca2+-Mg2+-ATPase and succinate dehydrogenase levels and myocardial Bcl-2 and Caspase-3 protein expression levels were significantly increased (P<0.05), the left ventricular end diastolic pressure, serum cTnI, CK-MB, TNF-α, IL-6, malondialdehyde and nitric oxide levels and myocardial Bax and cleaved Caspase-3 protein expression levels were significantly decreased (P<0.05). Conclusions: Polysaccharide can prevent the acute heart failure induced by adriamycin. The mechanism may be related to its anti-oxidative stress, anti-inflammation and inhibition of cardiac myocyte apoptosis.